https://www.high-endrolex.com/10

 Contemporary Materials 2015 - Савремени Материјали - confOrganiser.com

Contemporary Materials 2015 - Савремени Материјали

September 6 - 7, 2015.

STABILITY STUDY OF AMBROXOL HYDROCHLORIDE IN WATER MEDIUM BY HIGH PRESSURE LIQUID CHROMATOGRAPHY

Author(s):
1. Dijana Jelić, Republic of Srpska, Bosnia and Herzegovina
2. Irena Kasagić-Vujanović, Republic of Srpska, Bosnia and Herzegovina
3. Vesna Antunović, Medicinski fakultet Banja Luka , Republic of Srpska, Bosnia and Herzegovina
4. Saida Fazlagić, Republic of Srpska, Bosnia and Herzegovina


Abstract:
Ambroxol hydrochloride (AMB), (1s,4s)-4-((2-amino-3,5-dibromocyclohexyl)methylamino) cyclohexanol hydrochloride, is semi - synthetic derivative of vasicine obtained from Indian shrub Adhatoda vasica. In presented researche study, the focus was on stability of ambroxol hydrochloride (AMB), which is an active component in Flavamed® tablets. Using HPLC method combined with chemical kinetics we gave explanation on degradation and kinetics of AMB in commercial tablets. Degradation process was observed in neutral medium (water), at three different temperature: 25°C, 45°C and 70°C. All the relevant parameters, concerning stability of a drug, such as constant rate (k), activation energy (Ea), reaction order (n) and half-time (t1/2) were calculated. Obtained data are very important for the development of stable and safe drug product. Acknowledgements: This investigation is supported through the project 19/6-020/961-169/14financed by Ministry of Science and Technology of Republic of Srpska.

Key words:
Key words: stability of drug, HPLC, ambroxol hydrochloride, kinetics

Thematic field:
SYMPOSIUM C - Water

Date of abstract submission:
30.06.2016.

Conference:
Contemporary Materials 2016 - Savremeni Materijali

Applied paper from author

  • Login
  • Language
Copyright © 2021 confOrganiser.com. All rights reserved. | BitLab

https://www.high-endrolex.com/10